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KMID : 0361020160590040304
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Korean Journal of Otolaryngology - Head and Neck Surgery
2016 Volume.59 No. 4 p.304 ~ p.308
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Two Cases of Immunoglobulin G4-Related Sclerosing Disease Mimicking Nasopharyngeal Carcinoma
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Yoon Hyung-Joon
Park Woo-Sung
Ji Yong-Bae
Lee Seung-Hwan
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Abstract
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Immunoglobulin G4 (IgG4)-related sclerosing disease is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasma cell. This disease can occur in the salivary, lacrimal and pituitary gland in the head and neck region. The involvement of IgG4-related sclerosing disease at nasopharynx is extremely rare, so it is hard to make an accurate diagnosis. Recently, we have experienced two cases of IgG4-related sclerosing disease arising from the nasopharynx. Diffusely enhancing mass with surrounding bony erosion and increased 18-F fludeoxyglucose uptake was found at the nasopharynx, suggesting malignancy. But the cases were finally confirmed as IgG4-related sclerosig disease by punch biopsy and the symtoms improved with glucocorticoid therapy. We report our experiences with a literature review.
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KEYWORD
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Autoimmune, Immunoglobulin G, Nasopharynx, Sclerosing disease
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